{"id":7340,"date":"2026-04-14T12:01:22","date_gmt":"2026-04-14T12:01:22","guid":{"rendered":"https:\/\/oncopeptides.com\/?page_id=7340"},"modified":"2026-04-14T12:34:40","modified_gmt":"2026-04-14T12:34:40","slug":"test","status":"publish","type":"page","link":"https:\/\/oncopeptides.com\/sv\/test\/","title":{"rendered":"TEST"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"7340\" class=\"elementor elementor-7340\" data-elementor-post-type=\"page\">\n\t\t\t\t<style>\n                .elementor-element-c5b0bfd{\n                --padding-top: var(--webien-padding-top-l);\n                --padding-right: var(--webien-padding-right-l);\n                --padding-bottom: var(--webien-padding-bottom-l);\n                --padding-left: var(--webien-padding-left-l);\n                }\n            <\/style><div class=\"webien-container-padding-l elementor-element elementor-element-c5b0bfd dotted-bottom e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"c5b0bfd\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;fadeIn&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<style>\n                .elementor-element-df7b93a{\n                --padding-top: var(--webien-padding-top-none);\n                --padding-right: var(--webien-padding-right-none);\n                --padding-bottom: var(--webien-padding-bottom-none);\n                --padding-left: var(--webien-padding-left-none);\n                }\n            <\/style><div class=\"webien-container-padding-none elementor-element elementor-element-df7b93a e-con-full e-flex e-con e-child\" data-id=\"df7b93a\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f17906c elementor-widget elementor-widget-text-editor\" data-id=\"f17906c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Melflufen \u00e4r det f\u00f6rsta peptid-l\u00e4kemedelskonjugatet (PDC) med en alkylerande nyttolast. L\u00e4kemedlet utnyttjar peptidaser och esteraser som \u00e4r \u00f6veruttryckta i multipla myelomceller f\u00f6r att fris\u00e4tta en toxisk nyttolast inuti cellerna, i syfte att skada DNA och d\u00f6da cancerceller.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<style>\n                .elementor-element-52b7e70{\n                --padding-top: var(--webien-padding-top-l);\n                --padding-right: var(--webien-padding-right-l);\n                --padding-bottom: var(--webien-padding-bottom-l);\n                --padding-left: var(--webien-padding-left-l);\n                }\n            <\/style><div class=\"webien-container-padding-l elementor-element elementor-element-52b7e70 e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"52b7e70\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;fadeIn&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<style>\n                .elementor-element-4c1e4de{\n                --padding-top: var(--webien-padding-top-none);\n                --padding-right: var(--webien-padding-right-none);\n                --padding-bottom: var(--webien-padding-bottom-none);\n                --padding-left: var(--webien-padding-left-none);\n                }\n            <\/style><div class=\"webien-container-padding-none elementor-element elementor-element-4c1e4de e-con-full e-flex e-con e-child\" data-id=\"4c1e4de\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<style>\n                .elementor-element-3400f17{\n                --padding-top: var(--webien-padding-top-none);\n                --padding-right: var(--webien-padding-right-none);\n                --padding-bottom: var(--webien-padding-bottom-none);\n                --padding-left: var(--webien-padding-left-none);\n                }\n            <\/style><div class=\"lazyload image-optimizer webien-mkfmyoptfh webien-container-padding-none elementor-element elementor-element-3400f17 e-con-full haus-4-3 e-flex e-con e-child\" data-bgset=\"https:\/\/oncopeptides.com\/wp-content\/uploads\/2025\/12\/9735f309c2090dcfa2364a122991b2cffc5c23b4-scaled.jpg\" data-original=\"https:\/\/oncopeptides.com\/wp-content\/uploads\/2025\/12\/9735f309c2090dcfa2364a122991b2cffc5c23b4-scaled.jpg\" data-sizes=\"auto\" data-bgfit=\"cover\" data-bgpos=\"centre\" data-fullsizes=\"2560x1707\" data-customsizes=\"100|%\" data-custompositions=\"0px|0px\" data-useoriginal=\"0\" data-hasoverlay=\"1\" style=\"background-image:none;\" data-id=\"3400f17\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<\/div>\n\t\t<style>\n                .elementor-element-3bc0af2{\n                --padding-top: var(--webien-padding-top-none);\n                --padding-right: var(--webien-padding-right-none);\n                --padding-bottom: var(--webien-padding-bottom-none);\n                --padding-left: var(--webien-padding-left-none);\n                }\n            <\/style><div class=\"webien-container-padding-none elementor-element elementor-element-3bc0af2 e-con-full e-flex e-con e-child\" data-id=\"3bc0af2\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-953f2f9 elementor-widget elementor-widget-heading\" data-id=\"953f2f9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Melflufenmolekylen<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c4886cb elementor-widget elementor-widget-text-editor\" data-id=\"c4886cb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>In vitro \u00e4r melflufen 50 g\u00e5nger mer potent i myelomceller \u00e4n sj\u00e4lva den toxiska nyttolasten melfalan, tack vare en \u00f6kad koncentration av den toxiska nyttolasten i cellerna.<\/p><p>Melflufen har cytotoxisk aktivitet mot myelomcellinjer som \u00e4r resistenta mot andra behandlingar, inklusive alkylerare. Det h\u00e4mmar angiogenes och metastaseringsprocesser i prekliniska studier och \u00f6vervinner p53-brist-medierad resistens, en vanlig resistensmekanism mot myelombehandlingar. Melflufen inducerar snabbt irreversibla DNA-skador som leder till apoptos av myelomceller.  <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<style>\n                .elementor-element-23097ae{\n                --padding-top: var(--webien-padding-top-l);\n                --padding-right: var(--webien-padding-right-l);\n                --padding-bottom: var(--webien-padding-bottom-l);\n                --padding-left: var(--webien-padding-left-l);\n                }\n            <\/style><div class=\"webien-container-padding-l elementor-element elementor-element-23097ae dotted-bottom e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"23097ae\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;fadeIn&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<style>\n                .elementor-element-a48315c{\n                --padding-top: var(--webien-padding-top-none);\n                --padding-right: var(--webien-padding-right-none);\n                --padding-bottom: var(--webien-padding-bottom-none);\n                --padding-left: var(--webien-padding-left-none);\n                }\n            <\/style><div class=\"webien-container-padding-none elementor-element elementor-element-a48315c e-con-full e-flex e-con e-child\" data-id=\"a48315c\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<style>\n                .elementor-element-94b9d7a{\n                --padding-top: var(--webien-padding-top-none);\n                --padding-right: var(--webien-padding-right-none);\n                --padding-bottom: var(--webien-padding-bottom-none);\n                --padding-left: var(--webien-padding-left-none);\n                }\n            <\/style><div class=\"webien-container-padding-none elementor-element elementor-element-94b9d7a e-con-full e-flex e-con e-child\" data-id=\"94b9d7a\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-97a6649 elementor-widget elementor-widget-heading\" data-id=\"97a6649\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Verkningsmekanism<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<style>\n                .elementor-element-7483852{\n                --padding-top: var(--webien-padding-top-none);\n                --padding-right: var(--webien-padding-right-none);\n                --padding-bottom: var(--webien-padding-bottom-none);\n                --padding-left: var(--webien-padding-left-none);\n                }\n            <\/style><div class=\"webien-container-padding-none elementor-element elementor-element-7483852 e-con-full e-flex e-con e-child\" data-id=\"7483852\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2c27a9a elementor-widget elementor-widget-text-editor\" data-id=\"2c27a9a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Melfalanflufenamid, \u00e4ven k\u00e4nt som melflufen, \u00e4r ett f\u00f6rstklassigt (first-in-class) peptid-l\u00e4kemedelskonjugat (PDC) vid multipelt myelom som tillf\u00f6r cytotoxicitet in i tum\u00f6rcellerna.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-060c64e elementor-widget elementor-widget-text-editor\" data-id=\"060c64e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Melflufen tar sig fritt in i cellerna tack vare sin lipofilicitet, utan behov av transportproteiner. Melflufen hydrolyseras snabbt av peptidaser och esteraser, vilka \u00e4r \u00f6veruttryckta i tum\u00f6rceller. Hydrolysen skapar en koncentrationsgradient som driver ytterligare infl\u00f6de av melflufen i cellen, vilket resulterar i intracellul\u00e4r ackumulering av alkylerande \u00e4mnen. Detta leder till snabba och irreversibla skador p\u00e5 nukle\u00e4rt DNA och mitokondrie-DNA samt induktion av apoptos.   <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<style>\n                .elementor-element-2b06f76{\n                --padding-top: var(--webien-padding-top-none);\n                --padding-right: var(--webien-padding-right-none);\n                --padding-bottom: var(--webien-padding-bottom-none);\n                --padding-left: var(--webien-padding-left-none);\n                }\n            <\/style><div class=\"webien-container-padding-none elementor-element elementor-element-2b06f76 e-con-full e-flex e-con e-child\" data-id=\"2b06f76\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<style>\n                .elementor-element-752d1e9{\n                --padding-top: var(--webien-padding-top-none);\n                --padding-right: var(--webien-padding-right-none);\n                --padding-bottom: var(--webien-padding-bottom-none);\n                --padding-left: var(--webien-padding-left-none);\n                }\n            <\/style><div class=\"webien-container-padding-none elementor-element elementor-element-752d1e9 e-con-full e-flex e-con e-child\" data-id=\"752d1e9\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-bca7812 elementor-widget elementor-widget-n-accordion\" data-id=\"bca7812\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;n_accordion_animation_duration&quot;:{&quot;unit&quot;:&quot;ms&quot;,&quot;size&quot;:200,&quot;sizes&quot;:[]},&quot;default_state&quot;:&quot;expanded&quot;,&quot;max_items_expended&quot;:&quot;one&quot;}\" data-widget_type=\"nested-accordion.default\">\n\t\t\t\t\t\t\t<div class=\"e-n-accordion\" aria-label=\"Accordion. Open links with Enter or Space, close with Escape, and navigate with Arrow Keys\">\n\t\t\t\t\t\t<details id=\"item1\" class=\"e-n-accordion-item\" open>\n\t\t\t\t<summary class=\"e-n-accordion-item-title\" data-accordion-index=\"1\" tabindex=\"0\" aria-expanded=\"true\" aria-controls=\"item1\" >\n\t\t\t\t\t<span class='e-n-accordion-item-title-header'><div class=\"e-n-accordion-item-title-text\"> 1. Snabbt cellul\u00e4rt intr\u00e4de <\/div><\/span>\n\t\t\t\t\t\t\t\t\t<\/summary>\n\t\t\t\t<style>\n                .elementor-element-1f81ba4{\n                --padding-top: var(--webien-padding-top-none);\n                --padding-right: var(--webien-padding-right-none);\n                --padding-bottom: var(--webien-padding-bottom-none);\n                --padding-left: var(--webien-padding-left-none);\n                }\n            <\/style><div class=\"webien-container-padding-none elementor-element elementor-element-1f81ba4 e-con-full e-flex e-con e-child\" role=\"region\" aria-labelledby=\"item1\" data-id=\"1f81ba4\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ba179ec elementor-widget elementor-widget-text-editor\" data-id=\"ba179ec\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Melflufen tar sig fritt in i cellerna tack vare sin lipofilicitet, utan behov av transportproteiner.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t<details id=\"item2\" class=\"e-n-accordion-item\" >\n\t\t\t\t<summary class=\"e-n-accordion-item-title\" data-accordion-index=\"2\" tabindex=\"-1\" aria-expanded=\"false\" aria-controls=\"item2\" >\n\t\t\t\t\t<span class='e-n-accordion-item-title-header'><div class=\"e-n-accordion-item-title-text\"> 2. Enzym\u00f6veruttryck i tum\u00f6rceller <\/div><\/span>\n\t\t\t\t\t\t\t\t\t<\/summary>\n\t\t\t\t<style>\n                .elementor-element-b8a27cb{\n                --padding-top: var(--webien-padding-top-none);\n                --padding-right: var(--webien-padding-right-none);\n                --padding-bottom: var(--webien-padding-bottom-none);\n                --padding-left: var(--webien-padding-left-none);\n                }\n            <\/style><div class=\"webien-container-padding-none elementor-element elementor-element-b8a27cb e-con-full e-flex e-con e-child\" role=\"region\" aria-labelledby=\"item2\" data-id=\"b8a27cb\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-468f964 elementor-widget elementor-widget-text-editor\" data-id=\"468f964\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Peptidaser och esteraser \u00e4r enzymer som \u00e4r \u00f6veruttryckta i tum\u00f6rceller och viktiga f\u00f6r proteinhomeostas.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t<details id=\"item3\" class=\"e-n-accordion-item\" >\n\t\t\t\t<summary class=\"e-n-accordion-item-title\" data-accordion-index=\"3\" tabindex=\"-1\" aria-expanded=\"false\" aria-controls=\"item3\" >\n\t\t\t\t\t<span class='e-n-accordion-item-title-header'><div class=\"e-n-accordion-item-title-text\"> 3. Enzymatisk hydrolys och fris\u00e4ttning av nyttolast <\/div><\/span>\n\t\t\t\t\t\t\t\t\t<\/summary>\n\t\t\t\t<style>\n                .elementor-element-ffa6297{\n                --padding-top: var(--webien-padding-top-none);\n                --padding-right: var(--webien-padding-right-none);\n                --padding-bottom: var(--webien-padding-bottom-none);\n                --padding-left: var(--webien-padding-left-none);\n                }\n            <\/style><div class=\"webien-container-padding-none elementor-element elementor-element-ffa6297 e-con-full e-flex e-con e-child\" role=\"region\" aria-labelledby=\"item3\" data-id=\"ffa6297\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-226f153 elementor-widget elementor-widget-text-editor\" data-id=\"226f153\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Melflufen \u00e4r ett PDC som utnyttjar \u00f6veruttrycket av peptidaser inuti tum\u00f6rceller och hydrolyseras snabbt f\u00f6r att fris\u00e4tta cytotoxiska hydrofila alkylerande \u00e4mnen.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t<details id=\"item4\" class=\"e-n-accordion-item\" >\n\t\t\t\t<summary class=\"e-n-accordion-item-title\" data-accordion-index=\"4\" tabindex=\"-1\" aria-expanded=\"false\" aria-controls=\"item4\" >\n\t\t\t\t\t<span class='e-n-accordion-item-title-header'><div class=\"e-n-accordion-item-title-text\"> 4. Intracellul\u00e4r ackumulering av alkylerare <\/div><\/span>\n\t\t\t\t\t\t\t\t\t<\/summary>\n\t\t\t\t<style>\n                .elementor-element-fbd5cbc{\n                --padding-top: var(--webien-padding-top-none);\n                --padding-right: var(--webien-padding-right-none);\n                --padding-bottom: var(--webien-padding-bottom-none);\n                --padding-left: var(--webien-padding-left-none);\n                }\n            <\/style><div class=\"webien-container-padding-none elementor-element elementor-element-fbd5cbc e-con-full e-flex e-con e-child\" role=\"region\" aria-labelledby=\"item4\" data-id=\"fbd5cbc\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-fdd391c elementor-widget elementor-widget-text-editor\" data-id=\"fdd391c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Den snabba hydrolysen av melflufen skapar en koncentrationsgradient som driver ytterligare infl\u00f6de av melflufen i cellen, vilket resulterar i en intracellul\u00e4r topp av alkylerande \u00e4mnen.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t<details id=\"item5\" class=\"e-n-accordion-item\" >\n\t\t\t\t<summary class=\"e-n-accordion-item-title\" data-accordion-index=\"5\" tabindex=\"-1\" aria-expanded=\"false\" aria-controls=\"item5\" >\n\t\t\t\t\t<span class='e-n-accordion-item-title-header'><div class=\"e-n-accordion-item-title-text\"> 5. Irreversibel DNA-skada <\/div><\/span>\n\t\t\t\t\t\t\t\t\t<\/summary>\n\t\t\t\t<style>\n                .elementor-element-9bbc9eb{\n                --padding-top: var(--webien-padding-top-none);\n                --padding-right: var(--webien-padding-right-none);\n                --padding-bottom: var(--webien-padding-bottom-none);\n                --padding-left: var(--webien-padding-left-none);\n                }\n            <\/style><div class=\"webien-container-padding-none elementor-element elementor-element-9bbc9eb e-con-full e-flex e-con e-child\" role=\"region\" aria-labelledby=\"item5\" data-id=\"9bbc9eb\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9a2b8fe elementor-widget elementor-widget-text-editor\" data-id=\"9a2b8fe\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Alkylerande metaboliter av melflufen orsakar irreversibla nukle\u00e4ra och mitokondriella skador genom att l\u00e4nka samman DNA-str\u00e4ngar, vilket inducerar apoptos.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t<details id=\"item6\" class=\"e-n-accordion-item\" >\n\t\t\t\t<summary class=\"e-n-accordion-item-title\" data-accordion-index=\"6\" tabindex=\"-1\" aria-expanded=\"false\" aria-controls=\"item6\" >\n\t\t\t\t\t<span class='e-n-accordion-item-title-header'><div class=\"e-n-accordion-item-title-text\"> 6. Aktivitet i resistenta myelomceller <\/div><\/span>\n\t\t\t\t\t\t\t\t\t<\/summary>\n\t\t\t\t<style>\n                .elementor-element-0063de0{\n                --padding-top: var(--webien-padding-top-none);\n                --padding-right: var(--webien-padding-right-none);\n                --padding-bottom: var(--webien-padding-bottom-none);\n                --padding-left: var(--webien-padding-left-none);\n                }\n            <\/style><div class=\"webien-container-padding-none elementor-element elementor-element-0063de0 e-con-full e-flex e-con e-child\" role=\"region\" aria-labelledby=\"item6\" data-id=\"0063de0\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e180191 elementor-widget elementor-widget-text-editor\" data-id=\"e180191\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Melflufen kan \u00f6vervinna p53 (TP53)-brist-medierad resistens som ses vid konventionella alkylerare.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<style>\n                .elementor-element-2e35a06{\n                --padding-top: var(--webien-padding-top-none);\n                --padding-right: var(--webien-padding-right-none);\n                --padding-bottom: var(--webien-padding-bottom-none);\n                --padding-left: var(--webien-padding-left-none);\n                }\n            <\/style><div class=\"webien-container-padding-none elementor-element elementor-element-2e35a06 e-con-full accordion-images e-flex e-con e-child\" data-id=\"2e35a06\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<style>.webien-7iuaknrmhd::before{background-image: url(\"https:\/\/oncopeptides.com\/wp-content\/uploads\/2025\/12\/melflufen-mechanism_of_action-01.svg\");\nbackground-position: inherit;\nbackground-size:inherit !important;\nbackground-repeat:inherit;\n}}<\/style><style>\n                .elementor-element-0feb3e8{\n                --padding-top: var(--webien-padding-top-none);\n                --padding-right: var(--webien-padding-right-none);\n                --padding-bottom: var(--webien-padding-bottom-none);\n                --padding-left: var(--webien-padding-left-none);\n                }\n            <\/style><div class=\"lazyload image-optimizer webien-7iuaknrmhd webien-container-padding-none elementor-element elementor-element-0feb3e8 e-con-full accordion-image e-flex e-con e-child\" data-bgset=\"https:\/\/oncopeptides.com\/wp-content\/uploads\/2025\/12\/melflufen-mechanism_of_action-01.svg\" data-original=\"https:\/\/oncopeptides.com\/wp-content\/uploads\/2025\/12\/melflufen-mechanism_of_action-01.svg\" data-sizes=\"auto\" data-bgfit=\"cover\" data-bgpos=\"centre\" data-fullsizes=\"769x583\" data-customsizes=\"100|%\" data-custompositions=\"0px|0px\" data-useoriginal=\"0\" data-hasoverlay=\"0\" style=\"background-image:none;\" data-id=\"0feb3e8\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<\/div>\n\t\t<style>.webien-jtvbznyvuc::before{background-image: url(\"https:\/\/oncopeptides.com\/wp-content\/uploads\/2025\/12\/melflufen-mechanism_of_action-02.svg\");\nbackground-position: inherit;\nbackground-size:inherit !important;\nbackground-repeat:inherit;\n}}<\/style><style>\n                .elementor-element-579c6b5{\n                --padding-top: var(--webien-padding-top-none);\n                --padding-right: var(--webien-padding-right-none);\n                --padding-bottom: var(--webien-padding-bottom-none);\n                --padding-left: var(--webien-padding-left-none);\n                }\n            <\/style><div class=\"lazyload image-optimizer webien-jtvbznyvuc webien-container-padding-none elementor-element elementor-element-579c6b5 e-con-full accordion-image e-flex e-con e-child\" data-bgset=\"https:\/\/oncopeptides.com\/wp-content\/uploads\/2025\/12\/melflufen-mechanism_of_action-02.svg\" data-original=\"https:\/\/oncopeptides.com\/wp-content\/uploads\/2025\/12\/melflufen-mechanism_of_action-02.svg\" data-sizes=\"auto\" data-bgfit=\"cover\" data-bgpos=\"centre\" data-fullsizes=\"769x583\" data-customsizes=\"100|%\" data-custompositions=\"0px|0px\" data-useoriginal=\"0\" data-hasoverlay=\"0\" style=\"background-image:none;\" data-id=\"579c6b5\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<\/div>\n\t\t<style>.webien-ttwgn5sf3y::before{background-image: url(\"https:\/\/oncopeptides.com\/wp-content\/uploads\/2025\/12\/melflufen-mechanism_of_action-03.svg\");\nbackground-position: inherit;\nbackground-size:inherit !important;\nbackground-repeat:inherit;\n}}<\/style><style>\n                .elementor-element-19a0499{\n                --padding-top: var(--webien-padding-top-none);\n                --padding-right: var(--webien-padding-right-none);\n                --padding-bottom: var(--webien-padding-bottom-none);\n                --padding-left: var(--webien-padding-left-none);\n                }\n            <\/style><div class=\"lazyload image-optimizer webien-ttwgn5sf3y webien-container-padding-none elementor-element elementor-element-19a0499 e-con-full accordion-image e-flex e-con e-child\" data-bgset=\"https:\/\/oncopeptides.com\/wp-content\/uploads\/2025\/12\/melflufen-mechanism_of_action-03.svg\" data-original=\"https:\/\/oncopeptides.com\/wp-content\/uploads\/2025\/12\/melflufen-mechanism_of_action-03.svg\" data-sizes=\"auto\" data-bgfit=\"cover\" data-bgpos=\"centre\" data-fullsizes=\"769x583\" data-customsizes=\"100|%\" data-custompositions=\"0px|0px\" data-useoriginal=\"0\" data-hasoverlay=\"0\" style=\"background-image:none;\" data-id=\"19a0499\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<\/div>\n\t\t<style>.webien-g7i82yr7ag::before{background-image: url(\"https:\/\/oncopeptides.com\/wp-content\/uploads\/2025\/12\/melflufen-mechanism_of_action-04.svg\");\nbackground-position: inherit;\nbackground-size:inherit !important;\nbackground-repeat:inherit;\n}}<\/style><style>\n                .elementor-element-f54a09f{\n                --padding-top: var(--webien-padding-top-none);\n                --padding-right: var(--webien-padding-right-none);\n                --padding-bottom: var(--webien-padding-bottom-none);\n                --padding-left: var(--webien-padding-left-none);\n                }\n            <\/style><div class=\"lazyload image-optimizer webien-g7i82yr7ag webien-container-padding-none elementor-element elementor-element-f54a09f e-con-full accordion-image e-flex e-con e-child\" data-bgset=\"https:\/\/oncopeptides.com\/wp-content\/uploads\/2025\/12\/melflufen-mechanism_of_action-04.svg\" data-original=\"https:\/\/oncopeptides.com\/wp-content\/uploads\/2025\/12\/melflufen-mechanism_of_action-04.svg\" data-sizes=\"auto\" data-bgfit=\"cover\" data-bgpos=\"centre\" data-fullsizes=\"769x583\" data-customsizes=\"100|%\" data-custompositions=\"0px|0px\" data-useoriginal=\"0\" data-hasoverlay=\"0\" style=\"background-image:none;\" data-id=\"f54a09f\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<\/div>\n\t\t<style>.webien-hjaebrbvow::before{background-image: url(\"https:\/\/oncopeptides.com\/wp-content\/uploads\/2025\/12\/melflufen-mechanism_of_action-05.svg\");\nbackground-position: inherit;\nbackground-size:inherit !important;\nbackground-repeat:inherit;\n}}<\/style><style>\n                .elementor-element-67c90d1{\n                --padding-top: var(--webien-padding-top-none);\n                --padding-right: var(--webien-padding-right-none);\n                --padding-bottom: var(--webien-padding-bottom-none);\n                --padding-left: var(--webien-padding-left-none);\n                }\n            <\/style><div class=\"lazyload image-optimizer webien-hjaebrbvow webien-container-padding-none elementor-element elementor-element-67c90d1 e-con-full accordion-image e-flex e-con e-child\" data-bgset=\"https:\/\/oncopeptides.com\/wp-content\/uploads\/2025\/12\/melflufen-mechanism_of_action-05.svg\" data-original=\"https:\/\/oncopeptides.com\/wp-content\/uploads\/2025\/12\/melflufen-mechanism_of_action-05.svg\" data-sizes=\"auto\" data-bgfit=\"cover\" data-bgpos=\"centre\" data-fullsizes=\"769x583\" data-customsizes=\"100|%\" data-custompositions=\"0px|0px\" data-useoriginal=\"0\" data-hasoverlay=\"0\" style=\"background-image:none;\" data-id=\"67c90d1\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<\/div>\n\t\t<style>.webien-xcgao4sdmy::before{background-image: url(\"https:\/\/oncopeptides.com\/wp-content\/uploads\/2025\/12\/melflufen-mechanism_of_action-06.svg\");\nbackground-position: inherit;\nbackground-size:inherit !important;\nbackground-repeat:inherit;\n}}<\/style><style>\n                .elementor-element-4794527{\n                --padding-top: var(--webien-padding-top-none);\n                --padding-right: var(--webien-padding-right-none);\n                --padding-bottom: var(--webien-padding-bottom-none);\n                --padding-left: var(--webien-padding-left-none);\n                }\n            <\/style><div class=\"lazyload image-optimizer webien-xcgao4sdmy webien-container-padding-none elementor-element elementor-element-4794527 e-con-full accordion-image e-flex e-con e-child\" data-bgset=\"https:\/\/oncopeptides.com\/wp-content\/uploads\/2025\/12\/melflufen-mechanism_of_action-06.svg\" data-original=\"https:\/\/oncopeptides.com\/wp-content\/uploads\/2025\/12\/melflufen-mechanism_of_action-06.svg\" data-sizes=\"auto\" data-bgfit=\"cover\" data-bgpos=\"centre\" data-fullsizes=\"769x583\" data-customsizes=\"100|%\" data-custompositions=\"0px|0px\" data-useoriginal=\"0\" data-hasoverlay=\"0\" style=\"background-image:none;\" data-id=\"4794527\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4a772d2 haus-accordion elementor-widget elementor-widget-n-accordion\" data-id=\"4a772d2\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;n_accordion_animation_duration&quot;:{&quot;unit&quot;:&quot;ms&quot;,&quot;size&quot;:200,&quot;sizes&quot;:[]},&quot;default_state&quot;:&quot;all_collapsed&quot;,&quot;max_items_expended&quot;:&quot;one&quot;}\" data-widget_type=\"nested-accordion.default\">\n\t\t\t\t\t\t\t<div class=\"e-n-accordion\" aria-label=\"Accordion. Open links with Enter or Space, close with Escape, and navigate with Arrow Keys\">\n\t\t\t\t\t\t<details id=\"e-n-accordion-item-7800\" class=\"e-n-accordion-item\" >\n\t\t\t\t<summary class=\"e-n-accordion-item-title\" data-accordion-index=\"1\" tabindex=\"0\" aria-expanded=\"false\" aria-controls=\"e-n-accordion-item-7800\" >\n\t\t\t\t\t<span class='e-n-accordion-item-title-header'><div class=\"e-n-accordion-item-title-text\"> Referenser <\/div><\/span>\n\t\t\t\t\t\t\t<span class='e-n-accordion-item-title-icon'>\n\t\t\t<span class='e-opened' ><i aria-hidden=\"true\" class=\"onco onco-Minus\"><\/i><\/span>\n\t\t\t<span class='e-closed'><i aria-hidden=\"true\" class=\"onco onco-Plus\"><\/i><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t<style>\n                .elementor-element-4265987{\n                --padding-top: var(--webien-padding-top-none);\n                --padding-right: var(--webien-padding-right-none);\n                --padding-bottom: var(--webien-padding-bottom-none);\n                --padding-left: var(--webien-padding-left-none);\n                }\n            <\/style><div class=\"webien-container-padding-none elementor-element elementor-element-4265987 e-con-full e-flex e-con e-child\" role=\"region\" aria-labelledby=\"e-n-accordion-item-7800\" data-id=\"4265987\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a2996cd elementor-widget elementor-widget-text-editor\" data-id=\"a2996cd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<ol><li>Chauhan D, et al. Clin Cancer Res. 2013;19:3019-3031. <\/li><li>Wickstr\u00f6m M, et al. Oncotarget. 2017;8:66641-66655.  <\/li><li>Wickstr\u00f6m M, et al. Biochem Pharmacol. 2010;79:1281-1290.  <\/li><li>Gullbo J, et al. J Drug Target. 2003;11:355-363.  <\/li><li>Ray A, et al. Br J Haematol. 2016;174:397-409.  <\/li><li>Taylor A. FASEB J. 1993;32:290-298.<\/li><li>Holstein S.A., et al. Curr Cancer Drug Targets. 2023;23(1):25-46.  <\/li><li>Hitzerd SM, et al. Amino Acids. 2014;46(4):793-808.  <\/li><li>Miettinen JJ, et al. Cancers. 2021;13(7):1527.  <\/li><li>Kumari R, et al. Br J Cancer. 2021;124(8):1428-1436.  <\/li><li>Slipicevic A, et al. Poster presenterad vid: American Association for Cancer Research (AACR) Annual Meeting 2020; 22\u201324 juni 2020; virtuell presentation. Poster 1843.  <\/li><li>Kl\u00e1ra \u00c1cs et al. Presenterad vid: 10th World Congress on Controversies in Multiple Myeloma; 23\u201326 maj 2024; Paris, Frankrike &amp; online. <\/li><li>Westermark U, et al. Biochem Biophys Res Commun.  2023:656:122-130.<\/li><li>Haney et al. Poster presenterad vid: the 26th Congress of the European Hematology Association (EHA) 2021; 13\u201319 juni 2021; virtuell presentation. Poster EP945  <\/li><li>Byrgazov K, et al. ASH 2020. Abs 2274  <\/li><li>Strese S, et al. Biochem Pharmacol. 2013; 86:888-895.  <\/li><li>Poster presenterad vid: European Society of Medical Oncology (ESMO) Annual Meeting; 27 september\u20131 oktober 2019; Barcelona, Spanien. <\/li><li>Mateos MV, et al. ASH 2020. Poster 3237.  <\/li><\/ol>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<style>\n                .elementor-element-d06ac75{\n                --padding-top: var(--webien-padding-top-l);\n                --padding-right: var(--webien-padding-right-l);\n                --padding-bottom: var(--webien-padding-bottom-l);\n                --padding-left: var(--webien-padding-left-l);\n                }\n            <\/style><div class=\"webien-container-padding-l elementor-element elementor-element-d06ac75 e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"d06ac75\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;fadeIn&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<style>\n                .elementor-element-cd61a6e{\n                --padding-top: var(--webien-padding-top-none);\n                --padding-right: var(--webien-padding-right-none);\n                --padding-bottom: var(--webien-padding-bottom-none);\n                --padding-left: var(--webien-padding-left-none);\n                }\n            <\/style><div class=\"webien-container-padding-none elementor-element elementor-element-cd61a6e e-con-full e-flex e-con e-child\" data-id=\"cd61a6e\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<style>.webien-7ulwcotjm2::before{background-image: url(\"https:\/\/wrooom.webien.io\/eyJpbWFnZVVybCI6Imh0dHBzOi8vb25jb3BlcHRpZGVzLmNvbS93cC1jb250ZW50L3VwbG9hZHMvMjAyNS8xMi9pbWFnZS0zMi5qcGciLCJwdWJsaWNLZXkiOiJub0tleSIsImVkaXRzIjp7InJlc2l6ZSI6eyJ3aWR0aCI6MzAwLCJoZWlnaHQiOjMwMCwiZml0Ijoib3V0c2lkZSIsInBvc2l0aW9uIjoiYXR0ZW50aW9uIiwid2l0aG91dEVubGFyZ2VtZW50Ijp0cnVlfSwiYmx1ciI6OH19\");\nbackground-position: inherit;\nbackground-size:inherit !important;\nbackground-repeat:inherit;\n}}<\/style><style>\n                .elementor-element-258f057{\n                --padding-top: var(--webien-padding-top-none);\n                --padding-right: var(--webien-padding-right-none);\n                --padding-bottom: var(--webien-padding-bottom-none);\n                --padding-left: var(--webien-padding-left-none);\n                }\n            <\/style><div class=\"lazyload image-optimizer webien-7ulwcotjm2 webien-container-padding-none elementor-element elementor-element-258f057 e-con-full haus-4-3 e-flex e-con e-child\" data-bgset=\"https:\/\/oncopeptides.com\/wp-content\/uploads\/2025\/12\/image-32.jpg\" data-original=\"https:\/\/oncopeptides.com\/wp-content\/uploads\/2025\/12\/image-32.jpg\" data-sizes=\"auto\" data-bgfit=\"cover\" data-bgpos=\"centre\" data-fullsizes=\"656x492\" data-customsizes=\"100|%\" data-custompositions=\"0px|0px\" data-useoriginal=\"0\" data-hasoverlay=\"0\" style=\"background-image:none;\" data-id=\"258f057\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<\/div>\n\t\t<style>\n                .elementor-element-3a57184{\n                --padding-top: var(--webien-padding-top-none);\n                --padding-right: var(--webien-padding-right-none);\n                --padding-bottom: var(--webien-padding-bottom-none);\n                --padding-left: var(--webien-padding-left-none);\n                }\n            <\/style><div class=\"webien-container-padding-none elementor-element elementor-element-3a57184 e-con-full e-flex e-con e-child\" data-id=\"3a57184\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e182786 elementor-widget elementor-widget-heading\" data-id=\"e182786\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">V\u00e5rt fokus<\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9794b61 elementor-widget elementor-widget-heading\" data-id=\"9794b61\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Multipelt myelom<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c6c7022 elementor-widget elementor-widget-text-editor\" data-id=\"c6c7022\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Multipelt myelom \u00e4r en obotlig blodcancer. Symtom som skelettsm\u00e4rta, tr\u00f6tthet och infektioner minskar livskvaliteten avsev\u00e4rt. Trots framsteg inom behandling f\u00e5r de flesta patienter s\u00e5 sm\u00e5ningom \u00e5terfall och blir resistenta mot alla tillg\u00e4ngliga terapier, vilket skapar ett kritiskt behov av innovativa alternativ.  <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b100dd1 elementor-widget elementor-widget-button\" data-id=\"b100dd1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/oncopeptides.com\/sv\/forskning\/multipelt-myelom\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">L\u00e4s mer<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<style>\n                .elementor-element-0db6642{\n                --padding-top: var(--webien-padding-top-none);\n                --padding-right: var(--webien-padding-right-none);\n                --padding-bottom: var(--webien-padding-bottom-none);\n                --padding-left: var(--webien-padding-left-none);\n                }\n            <\/style><div class=\"webien-container-padding-none elementor-element elementor-element-0db6642 e-con-full e-flex e-con e-parent\" data-id=\"0db6642\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f5a0b99 elementor-widget elementor-widget-spacer\" data-id=\"f5a0b99\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Melflufen \u00e4r det f\u00f6rsta peptid-l\u00e4kemedelskonjugatet (PDC) med en alkylerande nyttolast. L\u00e4kemedlet utnyttjar peptidaser och esteraser som \u00e4r \u00f6veruttryckta i multipla myelomceller f\u00f6r att fris\u00e4tta en toxisk nyttolast inuti cellerna, i syfte att skada DNA och d\u00f6da cancerceller. Melflufenmolekylen In vitro \u00e4r melflufen 50 g\u00e5nger mer potent i myelomceller \u00e4n sj\u00e4lva den toxiska nyttolasten melfalan, tack [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"protected-content":[],"class_list":["post-7340","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/oncopeptides.com\/sv\/wp-json\/wp\/v2\/pages\/7340","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/oncopeptides.com\/sv\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/oncopeptides.com\/sv\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/oncopeptides.com\/sv\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/oncopeptides.com\/sv\/wp-json\/wp\/v2\/comments?post=7340"}],"version-history":[{"count":7,"href":"https:\/\/oncopeptides.com\/sv\/wp-json\/wp\/v2\/pages\/7340\/revisions"}],"predecessor-version":[{"id":7358,"href":"https:\/\/oncopeptides.com\/sv\/wp-json\/wp\/v2\/pages\/7340\/revisions\/7358"}],"wp:attachment":[{"href":"https:\/\/oncopeptides.com\/sv\/wp-json\/wp\/v2\/media?parent=7340"}],"wp:term":[{"taxonomy":"protected-content","embeddable":true,"href":"https:\/\/oncopeptides.com\/sv\/wp-json\/wp\/v2\/protected-content?post=7340"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}