{"id":8307,"date":"2026-10-12T16:56:33","date_gmt":"2026-10-12T14:56:33","guid":{"rendered":"https:\/\/oncopeptides.com\/?page_id=8307"},"modified":"2026-10-14T15:49:41","modified_gmt":"2026-10-14T13:49:41","slug":"oncopeptides-rapporterar-genombrott-i-kampen-mot-aggressiv-hjarncancer","status":"publish","type":"page","link":"https:\/\/oncopeptides.com\/sv\/oncopeptides-rapporterar-genombrott-i-kampen-mot-aggressiv-hjarncancer\/","title":{"rendered":"Oncopeptides rapporterar genombrott i kampen mot aggressiv hj\u00e4rncancer"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"8307\" class=\"elementor elementor-8307\" data-elementor-post-type=\"page\">\n\t\t\t\t<style>\n                .elementor-element-b7bf6c1{\n                --padding-top: var(--webien-padding-top-default);\n                --padding-right: var(--webien-padding-right-default);\n                --padding-bottom: var(--webien-padding-bottom-default);\n                --padding-left: 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       <\/div>\n        <\/div>\n\n\n\n\n    <\/div>\n\n\n<\/div>\n\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-458ad8e dotted-divider elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"458ad8e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a2fc9ef elementor-widget elementor-widget-text-editor\" data-id=\"a2fc9ef\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><strong>Oncopeptides har tagit ett viktigt steg fram\u00e5t i utvecklingen av behandling f\u00f6r glioblastom, en aggressiv form av hj\u00e4rncancer. I en interimsanalys fr\u00e5n den p\u00e5g\u00e5ende Window-of-Opportunity-studien i Oslo bekr\u00e4ftar data fr\u00e5n de f\u00f6rsta patienterna att bolagets peptiddrogkonjugatplattform, PDC, passerar blod-hj\u00e4rnbarri\u00e4ren och n\u00e5r tum\u00f6rv\u00e4vnad i farmakologiskt relevanta koncentrationer.<\/strong><\/p><p>Den positiva datan presenterades vid bolagets investeraruppdatering p\u00e5 m\u00e5ndagen den 12 oktober. Analysen omfattar tre av fem patienter i studiens f\u00f6rsta kohort, och enligt vd Sofia Heigis bekr\u00e4ftar resultaten det bolaget tidigare sett i prekliniska modeller.<\/p><p>\u201dGenom att bekr\u00e4fta en meningsfull penetration \u00f6ver blod-hj\u00e4rnbarri\u00e4ren har vi visat att PDC:erna klarar en av de st\u00f6rsta utmaningarna inom l\u00e4kemedelsutveckling f\u00f6r CNS-tum\u00f6rer (tum\u00f6rer i centrala nervsystemet)\u201d, sade Heigis under presentationen.<\/p><p><a href=\"https:\/\/open.spotify.com\/episode\/2w0KuH7p6MRguUlUgRfO4K\" target=\"_blank\" rel=\"noopener\">Lyssna p\u00e5 v\u00e5r podd Oncopeptalks om genombrottet i glioblastom h\u00e4r<\/a><\/p><p><a href=\"https:\/\/oncopeptides.com\/sv\/pressmeddelanden\/oncopeptides-bekraftar-passage-av-blod-hjarnbarriaren-baserat-pa-data-fran-de-forsta-patienterna-i-window-of-opportunity-studie-i-glioblastom\/\">L\u00e4s pressmeddelandet fr\u00e5n Oncopeptides h\u00e4r<\/a><\/p><p><a href=\"https:\/\/events.inderes.com\/oncopeptides\/investor-update-2026\" target=\"_blank\" rel=\"noopener\">Se investeraruppdateringen h\u00e4r<\/a><\/p><h2>Barri\u00e4ren som stoppat decennier av forskning<\/h2><p>Glioblastom \u00e4r den vanligaste och mest aggressiva formen av prim\u00e4r hj\u00e4rncancer. Sjukdomen \u00e5terfaller i princip alltid, har i dag ingen botande behandling och ger en median\u00f6verlevnad p\u00e5 endast 12 till 15 m\u00e5nader trots kirurgi, str\u00e5lning och kemoterapi.<\/p><p>Enligt Heigis \u00e4r begr\u00e4nsad penetration \u00f6ver blod-hj\u00e4rnbarri\u00e4ren en huvudorsak till att \u00f6ver 90 procent av onkologil\u00e4kemedel misslyckas inom omr\u00e5det. L\u00e4kemedel som fungerar i kroppen n\u00e5r helt enkelt inte hj\u00e4rntum\u00f6ren i tillr\u00e4ckligt h\u00f6g koncentration.<\/p><p>Dagens standardbehandling, temozolomid, godk\u00e4ndes redan 2005. Oncopeptides menar att l\u00e4kemedlet bara n\u00e5r omkring 30 procent biotillg\u00e4nglighet i centrala nervsystemet och att m\u00e5nga patienter f\u00e5r liten eller ingen nytta p\u00e5 grund av resistensmekanismer.<\/p><h2>PDC:erna ska sl\u00e5 mot tum\u00f6rcellens energiproduktion<\/h2><p>Oncopeptides peptiddrogkonjugat \u00e4r konstruerade f\u00f6r att ta sig in i cancerceller, d\u00e4r de fris\u00e4tter alkalerande \u00e4mnen. Bolaget beskriver mekanismen som dubbelriktad: l\u00e4kemedlet ska skada b\u00e5de DNA i cellk\u00e4rnan och DNA i mitokondrierna, tum\u00f6rcellens energiproduktion.<\/p><p>Enligt Heigis kan skador p\u00e5 mitokondriellt DNA st\u00e4nga av cellens \u201dkraftverk\u201d och trigga programmerad celld\u00f6d. Det \u00e4r ocks\u00e5 en f\u00f6rklaring till varf\u00f6r bolaget tror att plattformen kan vara verksam \u00e4ven n\u00e4r konventionella alkalerande l\u00e4kemedel m\u00f6ter resistens.<\/p><p>\u201dPlattformen \u00e4r inte ett opr\u00f6vat laboratoriekoncept. Den \u00e4r redan kommersiellt och kliniskt validerad\u201d, sade Heigis, med h\u00e4nvisning till att bolagets l\u00e4kemedel har anv\u00e4nts hos \u00f6ver 1 000 patienter i Europa.<\/p><h2>F\u00f6rsta patienten \u00e4r kvar i behandling<\/h2><p>Ut\u00f6ver de tre analyserade patienterna i f\u00f6rsta kohorten behandlas tv\u00e5 patienter i en \u00f6ppen f\u00f6rl\u00e4ngningsarm. Den lades till av etiska sk\u00e4l, f\u00f6r att patienter utan kvarvarande behandlingsalternativ ska kunna forts\u00e4tta med studiel\u00e4kemedlet om l\u00e4kare och patient s\u00e5 \u00f6nskar.<\/p><p>Den f\u00f6rsta patienten i studien har nu f\u00e5tt fem behandlingscykler, motsvarande fem m\u00e5nader. Heigis var noga med att betona att det inte g\u00e5r att dra n\u00e5gra slutsatser om behandlingseffekt av en enskild patient. Samtidigt beskrev hon l\u00e4get som uppmuntrande, eftersom patienten har en mycket aggressiv sjukdom och tidigare progredierat snabbt efter b\u00e5de standardbehandling och ett off-label-alternativ.<\/p><p>\u201dVi kan f\u00f6rst\u00e5s inte dra n\u00e5gra effekt slutsatser baserat p\u00e5 en patient\u201d, sade Heigis. \u201dMen med tanke p\u00e5 att patienten har en s\u00e5 aggressiv sjukdom \u00e4r det gl\u00e4djande f\u00f6r oss alla att patienten fortfarande \u00e4r kvar p\u00e5 l\u00e4kemedlet och m\u00e5r relativt bra.\u201d<\/p><p><img decoding=\"async\" class=\"alignnone size-full wp-image-8315\" src=\"https:\/\/oncopeptides.com\/wp-content\/uploads\/2026\/10\/image_73c31ce8.jpg\" alt=\"\" width=\"1280\" height=\"816\" srcset=\"https:\/\/oncopeptides.com\/wp-content\/uploads\/2026\/10\/image_73c31ce8.jpg 1280w, https:\/\/oncopeptides.com\/wp-content\/uploads\/2026\/10\/image_73c31ce8-300x191.jpg 300w, https:\/\/oncopeptides.com\/wp-content\/uploads\/2026\/10\/image_73c31ce8-1024x653.jpg 1024w, https:\/\/oncopeptides.com\/wp-content\/uploads\/2026\/10\/image_73c31ce8-768x490.jpg 768w\" sizes=\"(max-width: 1280px) 100vw, 1280px\" \/><\/p><h2>N\u00e4sta steg: fullst\u00e4ndig data n\u00e4sta \u00e5r<\/h2><p>Oncopeptides ska nu fullf\u00f6lja inkluderingen i den f\u00f6rsta kohorten, \u00f6ppna den andra kohorten under \u00e5ret och analysera farmakokinetik, v\u00e4vnadsf\u00f6rdelning och farmakodynamik. En fullst\u00e4ndig dataavl\u00e4sning v\u00e4ntas n\u00e4sta \u00e5r.<\/p><p>Resultaten ska sedan ligga till grund f\u00f6r bolagets beslut om fortsatt klinisk utveckling och regulatorisk strategi inom neuroonkologi. Bolaget lyfter ocks\u00e5 fram att tre prekliniska abstract presenterades vid EANO-kongressen i Rom f\u00f6rra m\u00e5naden, varav ett kortlistades f\u00f6r kongressens posterpris.<\/p><p>Heigis r\u00e4knar med att den globala marknaden f\u00f6r glioblastombehandling kan v\u00e4xa till 8 miljarder dollar till 2035. F\u00f6r Oncopeptides handlar beskedet d\u00e4rf\u00f6r inte bara om vetenskap, utan ocks\u00e5 om en potentiell breddning bortom bolagets etablerade verksamhet inom multipelt myelom.<\/p><p>\u201dMed detta fynd \u00e4r vi ett steg n\u00e4rmare att kunna st\u00f6tta patienter med ett mycket stort obehandlat behov\u201d, sade Heigis. \u201dVi \u00e4r ocks\u00e5 ett steg n\u00e4rmare att kunna frig\u00f6ra v\u00e4rde f\u00f6r v\u00e5ra aktie\u00e4gare.\u201d<\/p><p><a href=\"https:\/\/open.spotify.com\/episode\/2w0KuH7p6MRguUlUgRfO4K\" target=\"_blank\" rel=\"noopener\">Lyssna p\u00e5 v\u00e5r podd Oncopeptalks om genombrottet i glioblastom h\u00e4r<\/a><\/p><p><a href=\"https:\/\/oncopeptides.com\/sv\/pressmeddelanden\/oncopeptides-bekraftar-passage-av-blod-hjarnbarriaren-baserat-pa-data-fran-de-forsta-patienterna-i-window-of-opportunity-studie-i-glioblastom\/\">L\u00e4s pressmeddelandet fr\u00e5n Oncopeptides h\u00e4r<\/a><\/p><p><a 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class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Home \/ Oncopeptides rapporterar genombrott i kampen mot aggressiv hj\u00e4rncancer Oncopeptides rapporterar genombrott i kampen mot aggressiv hj\u00e4rncancer On this page {{chapter.title}} {{chapter.title}} {{chapter.title}} {{chapter.title}} Oncopeptides har tagit ett viktigt steg fram\u00e5t i utvecklingen av behandling f\u00f6r glioblastom, en aggressiv form av hj\u00e4rncancer. I en interimsanalys fr\u00e5n den p\u00e5g\u00e5ende Window-of-Opportunity-studien i Oslo bekr\u00e4ftar data fr\u00e5n [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"protected-content":[],"class_list":["post-8307","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/oncopeptides.com\/sv\/wp-json\/wp\/v2\/pages\/8307","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/oncopeptides.com\/sv\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/oncopeptides.com\/sv\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/oncopeptides.com\/sv\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/oncopeptides.com\/sv\/wp-json\/wp\/v2\/comments?post=8307"}],"version-history":[{"count":19,"href":"https:\/\/oncopeptides.com\/sv\/wp-json\/wp\/v2\/pages\/8307\/revisions"}],"predecessor-version":[{"id":8409,"href":"https:\/\/oncopeptides.com\/sv\/wp-json\/wp\/v2\/pages\/8307\/revisions\/8409"}],"wp:attachment":[{"href":"https:\/\/oncopeptides.com\/sv\/wp-json\/wp\/v2\/media?parent=8307"}],"wp:term":[{"taxonomy":"protected-content","embeddable":true,"href":"https:\/\/oncopeptides.com\/sv\/wp-json\/wp\/v2\/protected-content?post=8307"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}