{"id":7429,"date":"2026-04-22T08:40:31","date_gmt":"2026-04-22T08:40:31","guid":{"rendered":"https:\/\/oncopeptides.com\/science\/melflufen\/"},"modified":"2026-04-28T09:38:38","modified_gmt":"2026-04-28T09:38:38","slug":"melflufen","status":"publish","type":"science","link":"https:\/\/oncopeptides.com\/sv\/forskning\/melflufen\/","title":{"rendered":"Melflufen"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"7429\" class=\"elementor elementor-7429 elementor-7424\" data-elementor-post-type=\"science\">\n\t\t\t\t<style>\n                .elementor-element-82c6a25{\n                --padding-top: var(--webien-padding-top-l);\n                --padding-right: var(--webien-padding-right-l);\n                --padding-bottom: var(--webien-padding-bottom-l);\n                --padding-left: var(--webien-padding-left-l);\n                }\n            <\/style><div class=\"webien-container-padding-l elementor-element elementor-element-82c6a25 dotted-bottom e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"82c6a25\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;fadeIn&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<style>\n                .elementor-element-e567b2d{\n                --padding-top: var(--webien-padding-top-none);\n                --padding-right: var(--webien-padding-right-none);\n                --padding-bottom: var(--webien-padding-bottom-none);\n                --padding-left: var(--webien-padding-left-none);\n                }\n            <\/style><div class=\"webien-container-padding-none elementor-element elementor-element-e567b2d e-con-full e-flex e-con e-child\" data-id=\"e567b2d\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f69f5f6 elementor-widget elementor-widget-text-editor\" data-id=\"f69f5f6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Melflufen \u00e4r det f\u00f6rsta peptidl\u00e4kemedelskonjugatet (PDC) med en alkylerande nyttolast. L\u00e4kemedlet utnyttjar peptidaser och esteraser, som \u00f6veruttrycks i myelomceller, f\u00f6r att fris\u00e4tta en toxisk nyttolast inuti cellerna, skada DNA och d\u00f6da cancerceller. <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<style>\n                .elementor-element-e8b1ca7{\n                --padding-top: var(--webien-padding-top-l);\n                --padding-right: var(--webien-padding-right-l);\n                --padding-bottom: var(--webien-padding-bottom-l);\n                --padding-left: var(--webien-padding-left-l);\n                }\n            <\/style><div class=\"webien-container-padding-l elementor-element elementor-element-e8b1ca7 e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"e8b1ca7\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;fadeIn&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<style>\n                .elementor-element-adbb5cc{\n                --padding-top: var(--webien-padding-top-none);\n                --padding-right: var(--webien-padding-right-none);\n                --padding-bottom: var(--webien-padding-bottom-none);\n                --padding-left: var(--webien-padding-left-none);\n                }\n            <\/style><div class=\"webien-container-padding-none elementor-element elementor-element-adbb5cc e-con-full e-flex e-con e-child\" data-id=\"adbb5cc\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<style>\n                .elementor-element-e124c24{\n                --padding-top: var(--webien-padding-top-none);\n                --padding-right: var(--webien-padding-right-none);\n                --padding-bottom: var(--webien-padding-bottom-none);\n                --padding-left: var(--webien-padding-left-none);\n                }\n            <\/style><div class=\"lazyload image-optimizer webien-lbmclkilvb webien-container-padding-none elementor-element elementor-element-e124c24 e-con-full haus-4-3 e-flex e-con e-child\" data-bgset=\"https:\/\/oncopeptides.com\/wp-content\/uploads\/2025\/12\/molecule-lady.png\" data-original=\"https:\/\/oncopeptides.com\/wp-content\/uploads\/2025\/12\/molecule-lady.png\" data-sizes=\"auto\" data-bgfit=\"cover\" data-bgpos=\"centre\" data-fullsizes=\"1292x966\" data-customsizes=\"100|%\" data-custompositions=\"-16px|-58px\" data-useoriginal=\"0\" data-hasoverlay=\"1\" style=\"background-image:none;\" data-id=\"e124c24\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<\/div>\n\t\t<style>\n                .elementor-element-799dd96{\n                --padding-top: var(--webien-padding-top-none);\n                --padding-right: var(--webien-padding-right-none);\n                --padding-bottom: var(--webien-padding-bottom-none);\n                --padding-left: var(--webien-padding-left-none);\n                }\n            <\/style><div class=\"webien-container-padding-none elementor-element elementor-element-799dd96 e-con-full e-flex e-con e-child\" data-id=\"799dd96\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-341618a elementor-widget elementor-widget-heading\" data-id=\"341618a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Melflufenmolekylen<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9a37084 elementor-widget elementor-widget-text-editor\" data-id=\"9a37084\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>In vitro \u00e4r melflufen 50 g\u00e5nger mer potent i myelomceller \u00e4n den toxiska nyttolasten melfalan i sig, p\u00e5 grund av \u00f6kad koncentration av den toxiska nyttolasten i cellerna.<\/p><p>Melflufen har cytotoxisk aktivitet mot myelomcellinjer som \u00e4r resistenta mot andra behandlingar, inklusive alkylerare. Det h\u00e4mmar angiogenes och metastatiska processer i prekliniska studier och \u00f6vervinner p53-bristmedierad resistens, en vanlig resistensmekanism mot antimyelombehandlingar. Melflufen inducerar snabbt irreversibel DNA-skada som leder till apoptos av myelomceller.  <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<style>\n                .elementor-element-fcb3ce0{\n                --padding-top: var(--webien-padding-top-l);\n                --padding-right: var(--webien-padding-right-l);\n                --padding-bottom: var(--webien-padding-bottom-l);\n                --padding-left: var(--webien-padding-left-l);\n                }\n            <\/style><div class=\"webien-container-padding-l elementor-element elementor-element-fcb3ce0 dotted-bottom e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"fcb3ce0\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;fadeIn&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<style>\n                .elementor-element-cd65a4c{\n                --padding-top: var(--webien-padding-top-none);\n                --padding-right: var(--webien-padding-right-none);\n                --padding-bottom: var(--webien-padding-bottom-none);\n                --padding-left: var(--webien-padding-left-none);\n                }\n            <\/style><div class=\"webien-container-padding-none elementor-element elementor-element-cd65a4c e-con-full e-flex e-con e-child\" data-id=\"cd65a4c\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<style>\n                .elementor-element-ff887b9{\n                --padding-top: var(--webien-padding-top-none);\n                --padding-right: var(--webien-padding-right-none);\n                --padding-bottom: var(--webien-padding-bottom-none);\n                --padding-left: var(--webien-padding-left-none);\n                }\n            <\/style><div class=\"webien-container-padding-none elementor-element elementor-element-ff887b9 e-con-full e-flex e-con e-child\" data-id=\"ff887b9\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-87a7195 elementor-widget elementor-widget-heading\" data-id=\"87a7195\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Verkningsmekanism<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<style>\n                .elementor-element-02b666e{\n                --padding-top: var(--webien-padding-top-none);\n                --padding-right: var(--webien-padding-right-none);\n                --padding-bottom: var(--webien-padding-bottom-none);\n                --padding-left: var(--webien-padding-left-none);\n                }\n            <\/style><div class=\"webien-container-padding-none elementor-element elementor-element-02b666e e-con-full e-flex e-con e-child\" data-id=\"02b666e\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1c1678c elementor-widget elementor-widget-text-editor\" data-id=\"1c1678c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Melfalanflufenamid, \u00e4ven k\u00e4nt som melflufen, \u00e4r ett f\u00f6rstklassigt peptid-l\u00e4kemedelskonjugat (PDC) vid multipelt myelom som tillf\u00f6r cytotoxicitet till tum\u00f6rcellerna.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-56f92b7 elementor-widget elementor-widget-text-editor\" data-id=\"56f92b7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Melflufen tar sig fritt in i celler tack vare sin lipofilicitet, utan behov av transportproteiner. Melflufen hydrolyseras snabbt av peptidaser och esteraser, som \u00f6veruttrycks i tum\u00f6rceller. Hydrolysen skapar en koncentrationsgradient som driver ytterligare infl\u00f6de av melflufen in i cellen, vilket resulterar i intracellul\u00e4r ackumulering av alkylerande medel. Detta leder till snabb och irreversibel k\u00e4rn- och mitokondriell DNA-skada och induktion av apoptos.   <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<style>\n                .elementor-element-ec0a1d6{\n                --padding-top: var(--webien-padding-top-none);\n                --padding-right: var(--webien-padding-right-none);\n                --padding-bottom: var(--webien-padding-bottom-none);\n                --padding-left: var(--webien-padding-left-none);\n                }\n            <\/style><div class=\"webien-container-padding-none elementor-element elementor-element-ec0a1d6 e-con-full accordion-images-wrapper e-flex e-con e-child\" data-id=\"ec0a1d6\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<style>\n                .elementor-element-95f4b7f{\n                --padding-top: var(--webien-padding-top-none);\n                --padding-right: var(--webien-padding-right-none);\n                --padding-bottom: var(--webien-padding-bottom-none);\n                --padding-left: var(--webien-padding-left-none);\n                }\n            <\/style><div class=\"webien-container-padding-none elementor-element elementor-element-95f4b7f e-con-full e-flex e-con e-child\" data-id=\"95f4b7f\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9cb0be2 elementor-widget elementor-widget-n-accordion\" data-id=\"9cb0be2\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;n_accordion_animation_duration&quot;:{&quot;unit&quot;:&quot;ms&quot;,&quot;size&quot;:200,&quot;sizes&quot;:[]},&quot;default_state&quot;:&quot;expanded&quot;,&quot;max_items_expended&quot;:&quot;one&quot;}\" data-widget_type=\"nested-accordion.default\">\n\t\t\t\t\t\t\t<div class=\"e-n-accordion\" aria-label=\"Accordion. Open links with Enter or Space, close with Escape, and navigate with Arrow Keys\">\n\t\t\t\t\t\t<details id=\"item1\" class=\"e-n-accordion-item\" open>\n\t\t\t\t<summary class=\"e-n-accordion-item-title\" data-accordion-index=\"1\" tabindex=\"0\" aria-expanded=\"true\" aria-controls=\"item1\" >\n\t\t\t\t\t<span class='e-n-accordion-item-title-header'><div class=\"e-n-accordion-item-title-text\"> 1. Snabbt cellul\u00e4rt upptag <\/div><\/span>\n\t\t\t\t\t\t\t\t\t<\/summary>\n\t\t\t\t<style>\n                .elementor-element-2a989a4{\n                --padding-top: var(--webien-padding-top-none);\n                --padding-right: var(--webien-padding-right-none);\n                --padding-bottom: var(--webien-padding-bottom-none);\n                --padding-left: var(--webien-padding-left-none);\n                }\n            <\/style><div class=\"webien-container-padding-none elementor-element elementor-element-2a989a4 e-con-full e-flex e-con e-child\" role=\"region\" aria-labelledby=\"item1\" data-id=\"2a989a4\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-03b9c4e elementor-widget elementor-widget-text-editor\" data-id=\"03b9c4e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Melflufen tar sig fritt in i celler tack vare sin lipofilicitet, utan behov av transportproteiner.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t<details id=\"item2\" class=\"e-n-accordion-item\" >\n\t\t\t\t<summary class=\"e-n-accordion-item-title\" data-accordion-index=\"2\" tabindex=\"-1\" aria-expanded=\"false\" aria-controls=\"item2\" >\n\t\t\t\t\t<span class='e-n-accordion-item-title-header'><div class=\"e-n-accordion-item-title-text\"> 2. Enzym\u00f6veruttryck i tum\u00f6rceller <\/div><\/span>\n\t\t\t\t\t\t\t\t\t<\/summary>\n\t\t\t\t<style>\n                .elementor-element-9356de8{\n                --padding-top: var(--webien-padding-top-none);\n                --padding-right: var(--webien-padding-right-none);\n                --padding-bottom: var(--webien-padding-bottom-none);\n                --padding-left: var(--webien-padding-left-none);\n                }\n            <\/style><div class=\"webien-container-padding-none elementor-element elementor-element-9356de8 e-con-full e-flex e-con e-child\" role=\"region\" aria-labelledby=\"item2\" data-id=\"9356de8\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6d24589 elementor-widget elementor-widget-text-editor\" data-id=\"6d24589\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Peptidaser och esteraser \u00e4r enzymer som \u00f6veruttrycks i tum\u00f6rceller och \u00e4r viktiga f\u00f6r proteinhomeostasen.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t<details id=\"item3\" class=\"e-n-accordion-item\" >\n\t\t\t\t<summary class=\"e-n-accordion-item-title\" data-accordion-index=\"3\" tabindex=\"-1\" aria-expanded=\"false\" aria-controls=\"item3\" >\n\t\t\t\t\t<span class='e-n-accordion-item-title-header'><div class=\"e-n-accordion-item-title-text\"> 3. Enzymatisk hydrolys och fris\u00e4ttning av nyttolast <\/div><\/span>\n\t\t\t\t\t\t\t\t\t<\/summary>\n\t\t\t\t<style>\n                .elementor-element-3b89d56{\n                --padding-top: var(--webien-padding-top-none);\n                --padding-right: var(--webien-padding-right-none);\n                --padding-bottom: var(--webien-padding-bottom-none);\n                --padding-left: var(--webien-padding-left-none);\n                }\n            <\/style><div class=\"webien-container-padding-none elementor-element elementor-element-3b89d56 e-con-full e-flex e-con e-child\" role=\"region\" aria-labelledby=\"item3\" data-id=\"3b89d56\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e2aaab2 elementor-widget elementor-widget-text-editor\" data-id=\"e2aaab2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Melflufen \u00e4r ett PDC som utnyttjar \u00f6veruttrycket av peptidaser inuti tum\u00f6rceller och hydrolyseras snabbt f\u00f6r att fris\u00e4tta cytotoxiska hydrofila alkylerande medel.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t<details id=\"item4\" class=\"e-n-accordion-item\" >\n\t\t\t\t<summary class=\"e-n-accordion-item-title\" data-accordion-index=\"4\" tabindex=\"-1\" aria-expanded=\"false\" aria-controls=\"item4\" >\n\t\t\t\t\t<span class='e-n-accordion-item-title-header'><div class=\"e-n-accordion-item-title-text\"> 4. Intracellul\u00e4r ackumulering av alkylerare <\/div><\/span>\n\t\t\t\t\t\t\t\t\t<\/summary>\n\t\t\t\t<style>\n                .elementor-element-d95e679{\n                --padding-top: var(--webien-padding-top-none);\n                --padding-right: var(--webien-padding-right-none);\n                --padding-bottom: var(--webien-padding-bottom-none);\n                --padding-left: var(--webien-padding-left-none);\n                }\n            <\/style><div class=\"webien-container-padding-none elementor-element elementor-element-d95e679 e-con-full e-flex e-con e-child\" role=\"region\" aria-labelledby=\"item4\" data-id=\"d95e679\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4051d38 elementor-widget elementor-widget-text-editor\" data-id=\"4051d38\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Den snabba hydrolysen av melflufen skapar en koncentrationsgradient som driver ytterligare infl\u00f6de av melflufen in i cellen, vilket resulterar i en intracellul\u00e4r topp av alkylerande medel.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t<details id=\"item5\" class=\"e-n-accordion-item\" >\n\t\t\t\t<summary class=\"e-n-accordion-item-title\" data-accordion-index=\"5\" tabindex=\"-1\" aria-expanded=\"false\" aria-controls=\"item5\" >\n\t\t\t\t\t<span class='e-n-accordion-item-title-header'><div class=\"e-n-accordion-item-title-text\"> 5. Irreversibel DNA-skada <\/div><\/span>\n\t\t\t\t\t\t\t\t\t<\/summary>\n\t\t\t\t<style>\n                .elementor-element-e56f0f0{\n                --padding-top: var(--webien-padding-top-none);\n                --padding-right: var(--webien-padding-right-none);\n                --padding-bottom: var(--webien-padding-bottom-none);\n                --padding-left: var(--webien-padding-left-none);\n                }\n            <\/style><div class=\"webien-container-padding-none elementor-element elementor-element-e56f0f0 e-con-full e-flex e-con e-child\" role=\"region\" aria-labelledby=\"item5\" data-id=\"e56f0f0\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-00c6b0b elementor-widget elementor-widget-text-editor\" data-id=\"00c6b0b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Alkylerande metaboliter av melflufen orsakar irreversibel k\u00e4rn- och mitokondriell skada genom att l\u00e4nka DNA-str\u00e4ngar, vilket inducerar apoptos.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t<details id=\"item6\" class=\"e-n-accordion-item\" >\n\t\t\t\t<summary class=\"e-n-accordion-item-title\" data-accordion-index=\"6\" tabindex=\"-1\" aria-expanded=\"false\" aria-controls=\"item6\" >\n\t\t\t\t\t<span class='e-n-accordion-item-title-header'><div class=\"e-n-accordion-item-title-text\"> 6. Aktivitet i resistenta myelomceller <\/div><\/span>\n\t\t\t\t\t\t\t\t\t<\/summary>\n\t\t\t\t<style>\n                .elementor-element-dc6f8c8{\n                --padding-top: var(--webien-padding-top-none);\n                --padding-right: var(--webien-padding-right-none);\n                --padding-bottom: var(--webien-padding-bottom-none);\n                --padding-left: var(--webien-padding-left-none);\n                }\n            <\/style><div class=\"webien-container-padding-none elementor-element elementor-element-dc6f8c8 e-con-full e-flex e-con e-child\" role=\"region\" aria-labelledby=\"item6\" data-id=\"dc6f8c8\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-fec4964 elementor-widget elementor-widget-text-editor\" data-id=\"fec4964\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Melflufen kan \u00f6vervinna p53 (TP53)-bristmedierad resistens som ses vid konventionella alkylerare.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<style>\n                .elementor-element-88a6152{\n                --padding-top: var(--webien-padding-top-none);\n                --padding-right: var(--webien-padding-right-none);\n                --padding-bottom: var(--webien-padding-bottom-none);\n                --padding-left: var(--webien-padding-left-none);\n                }\n            <\/style><div class=\"webien-container-padding-none elementor-element elementor-element-88a6152 e-con-full accordion-images e-flex e-con e-child\" data-id=\"88a6152\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<style>.webien-cladxdt6ak::before{background-image: 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url(\"https:\/\/oncopeptides.com\/wp-content\/uploads\/2025\/12\/melflufen-mechanism_of_action-03.svg\");\nbackground-position: inherit;\nbackground-size:inherit !important;\nbackground-repeat:inherit;\n}}<\/style><style>\n                .elementor-element-242fa91{\n                --padding-top: var(--webien-padding-top-none);\n                --padding-right: var(--webien-padding-right-none);\n                --padding-bottom: var(--webien-padding-bottom-none);\n                --padding-left: var(--webien-padding-left-none);\n                }\n            <\/style><div class=\"lazyload image-optimizer webien-xryntgjqx8 webien-container-padding-none elementor-element elementor-element-242fa91 e-con-full accordion-image e-flex e-con e-child\" data-bgset=\"https:\/\/oncopeptides.com\/wp-content\/uploads\/2025\/12\/melflufen-mechanism_of_action-03.svg\" data-original=\"https:\/\/oncopeptides.com\/wp-content\/uploads\/2025\/12\/melflufen-mechanism_of_action-03.svg\" data-sizes=\"auto\" 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url(\"https:\/\/oncopeptides.com\/wp-content\/uploads\/2025\/12\/melflufen-mechanism_of_action-05.svg\");\nbackground-position: inherit;\nbackground-size:inherit !important;\nbackground-repeat:inherit;\n}}<\/style><style>\n                .elementor-element-8e29f76{\n                --padding-top: var(--webien-padding-top-none);\n                --padding-right: var(--webien-padding-right-none);\n                --padding-bottom: var(--webien-padding-bottom-none);\n                --padding-left: var(--webien-padding-left-none);\n                }\n            <\/style><div class=\"lazyload image-optimizer webien-0fy33pglty webien-container-padding-none elementor-element elementor-element-8e29f76 e-con-full accordion-image e-flex e-con e-child\" data-bgset=\"https:\/\/oncopeptides.com\/wp-content\/uploads\/2025\/12\/melflufen-mechanism_of_action-05.svg\" data-original=\"https:\/\/oncopeptides.com\/wp-content\/uploads\/2025\/12\/melflufen-mechanism_of_action-05.svg\" data-sizes=\"auto\" data-bgfit=\"cover\" data-bgpos=\"centre\" data-fullsizes=\"769x583\" data-customsizes=\"100|%\" data-custompositions=\"0px|0px\" data-useoriginal=\"0\" data-hasoverlay=\"0\" style=\"background-image:none;\" data-id=\"8e29f76\" data-element_type=\"container\" data-e-type=\"container\" id=\"img5\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<\/div>\n\t\t<style>.webien-wcqqirevax::before{background-image: url(\"https:\/\/oncopeptides.com\/wp-content\/uploads\/2025\/12\/melflufen-mechanism_of_action-06.svg\");\nbackground-position: inherit;\nbackground-size:inherit !important;\nbackground-repeat:inherit;\n}}<\/style><style>\n                .elementor-element-c5940ea{\n                --padding-top: var(--webien-padding-top-none);\n                --padding-right: var(--webien-padding-right-none);\n                --padding-bottom: var(--webien-padding-bottom-none);\n                --padding-left: var(--webien-padding-left-none);\n                }\n            <\/style><div class=\"lazyload image-optimizer webien-wcqqirevax webien-container-padding-none elementor-element elementor-element-c5940ea e-con-full accordion-image e-flex e-con e-child\" data-bgset=\"https:\/\/oncopeptides.com\/wp-content\/uploads\/2025\/12\/melflufen-mechanism_of_action-06.svg\" data-original=\"https:\/\/oncopeptides.com\/wp-content\/uploads\/2025\/12\/melflufen-mechanism_of_action-06.svg\" data-sizes=\"auto\" data-bgfit=\"cover\" data-bgpos=\"centre\" data-fullsizes=\"769x583\" data-customsizes=\"100|%\" data-custompositions=\"0px|0px\" data-useoriginal=\"0\" data-hasoverlay=\"0\" style=\"background-image:none;\" data-id=\"c5940ea\" data-element_type=\"container\" data-e-type=\"container\" id=\"img6\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f648377 haus-accordion elementor-widget elementor-widget-n-accordion\" data-id=\"f648377\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;n_accordion_animation_duration&quot;:{&quot;unit&quot;:&quot;ms&quot;,&quot;size&quot;:200,&quot;sizes&quot;:[]},&quot;default_state&quot;:&quot;all_collapsed&quot;,&quot;max_items_expended&quot;:&quot;one&quot;}\" data-widget_type=\"nested-accordion.default\">\n\t\t\t\t\t\t\t<div class=\"e-n-accordion\" aria-label=\"Accordion. Open links with Enter or Space, close with Escape, and navigate with Arrow Keys\">\n\t\t\t\t\t\t<details id=\"e-n-accordion-item-2580\" class=\"e-n-accordion-item\" >\n\t\t\t\t<summary class=\"e-n-accordion-item-title\" data-accordion-index=\"1\" tabindex=\"0\" aria-expanded=\"false\" aria-controls=\"e-n-accordion-item-2580\" >\n\t\t\t\t\t<span class='e-n-accordion-item-title-header'><div class=\"e-n-accordion-item-title-text\"> Referenser <\/div><\/span>\n\t\t\t\t\t\t\t<span class='e-n-accordion-item-title-icon'>\n\t\t\t<span class='e-opened' ><i aria-hidden=\"true\" class=\"onco onco-Minus\"><\/i><\/span>\n\t\t\t<span class='e-closed'><i aria-hidden=\"true\" class=\"onco onco-Plus\"><\/i><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t<style>\n                .elementor-element-d781033{\n                --padding-top: var(--webien-padding-top-none);\n                --padding-right: var(--webien-padding-right-none);\n                --padding-bottom: var(--webien-padding-bottom-none);\n                --padding-left: var(--webien-padding-left-none);\n                }\n            <\/style><div class=\"webien-container-padding-none elementor-element elementor-element-d781033 e-con-full e-flex e-con e-child\" role=\"region\" aria-labelledby=\"e-n-accordion-item-2580\" data-id=\"d781033\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a2ca2b7 elementor-widget elementor-widget-text-editor\" data-id=\"a2ca2b7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<ol><li>Chauhan D, et al. Clin Cancer Res. 2013;19:3019-3031. <\/li><li>Wickstr\u00f6m M, et al. Oncotarget. 2017;8:66641-66655.  <\/li><li>Wickstr\u00f6m M, et al. Biochem Pharmacol. 2010;79:1281-1290.  <\/li><li>Gullbo J, et al. J Drug Target. 2003;11:355-363.  <\/li><li>Ray A, et al. Br J Haematol. 2016;174:397-409.  <\/li><li>Taylor A. FASEB J. 1993;32:290-298.<\/li><li>Holstein S.A., et al. Curr Cancer Drug Targets. 2023;23(1):25-46.  <\/li><li>Hitzerd SM, et al. Amino Acids. 2014;46(4):793-808.  <\/li><li>Miettinen JJ, et al. Cancers. 2021;13(7):1527.  <\/li><li>Kumari R, et al. Br J Cancer. 2021;124(8):1428-1436.  <\/li><li>Slipicevic A, et al. Poster presenterad vid: American Association for Cancer Research (AACR) Annual Meeting 2020; 22\u201324 juni 2020; Virtuell presentation. Poster 1843.  <\/li><li>Kl\u00e1ra \u00c1cs et al. Presenterad vid: 10th World Congress on Controversies in Multiple Myeloma; 23-26 maj 2024; Paris, Frankrike &amp; Online. <\/li><li>Westermark U, et al. Biochem Biophys Res Commun.  2023:656:122-130.<\/li><li>Haney et al. Poster presenterad vid: 26th Congress of the European Hematology Association (EHA) 2021; 13-19 juni 2021; Virtuell presentation. Poster EP945  <\/li><li>Byrgazov K, et al. ASH 2020. Abs 2274  <\/li><li>Strese S, et al. Biochem Pharmacol. 2013; 86:888-895.  <\/li><li>Byrgazov K, et al. Poster presenterad vid: European Society of Medical Oncology (ESMO) Annual Meeting; 27 september-1 oktober 2019; Barcelona, Spanien. <\/li><li>Mateos MV, et al. ASH 2020. Poster 3237.  <\/li><\/ol>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<style>\n                .elementor-element-8988d70{\n                --padding-top: var(--webien-padding-top-l);\n                --padding-right: var(--webien-padding-right-l);\n                --padding-bottom: var(--webien-padding-bottom-l);\n                --padding-left: var(--webien-padding-left-l);\n                }\n            <\/style><div class=\"webien-container-padding-l elementor-element elementor-element-8988d70 e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"8988d70\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;fadeIn&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<style>\n                .elementor-element-ff3e904{\n                --padding-top: var(--webien-padding-top-none);\n                --padding-right: var(--webien-padding-right-none);\n                --padding-bottom: var(--webien-padding-bottom-none);\n                --padding-left: var(--webien-padding-left-none);\n                }\n            <\/style><div class=\"webien-container-padding-none elementor-element elementor-element-ff3e904 e-con-full e-flex e-con e-child\" data-id=\"ff3e904\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<style>.webien-col4d8joal::before{background-image: url(\"https:\/\/wrooom.webien.io\/eyJpbWFnZVVybCI6Imh0dHBzOi8vb25jb3BlcHRpZGVzLmNvbS93cC1jb250ZW50L3VwbG9hZHMvMjAyNS8xMi9pbWFnZS0zMi5qcGciLCJwdWJsaWNLZXkiOiJub0tleSIsImVkaXRzIjp7InJlc2l6ZSI6eyJ3aWR0aCI6MzAwLCJoZWlnaHQiOjMwMCwiZml0Ijoib3V0c2lkZSIsInBvc2l0aW9uIjoiYXR0ZW50aW9uIiwid2l0aG91dEVubGFyZ2VtZW50Ijp0cnVlfSwiYmx1ciI6OH19\");\nbackground-position: inherit;\nbackground-size:inherit !important;\nbackground-repeat:inherit;\n}}<\/style><style>\n                .elementor-element-c462d95{\n                --padding-top: var(--webien-padding-top-none);\n                --padding-right: var(--webien-padding-right-none);\n                --padding-bottom: var(--webien-padding-bottom-none);\n                --padding-left: var(--webien-padding-left-none);\n                }\n            <\/style><div class=\"lazyload image-optimizer webien-col4d8joal webien-container-padding-none elementor-element elementor-element-c462d95 e-con-full haus-4-3 e-flex e-con e-child\" data-bgset=\"https:\/\/oncopeptides.com\/wp-content\/uploads\/2025\/12\/image-32.jpg\" data-original=\"https:\/\/oncopeptides.com\/wp-content\/uploads\/2025\/12\/image-32.jpg\" data-sizes=\"auto\" data-bgfit=\"cover\" data-bgpos=\"centre\" data-fullsizes=\"656x492\" data-customsizes=\"100|%\" data-custompositions=\"0px|0px\" data-useoriginal=\"0\" data-hasoverlay=\"0\" style=\"background-image:none;\" data-id=\"c462d95\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<\/div>\n\t\t<style>\n                .elementor-element-55676ad{\n                --padding-top: var(--webien-padding-top-none);\n                --padding-right: var(--webien-padding-right-none);\n                --padding-bottom: var(--webien-padding-bottom-none);\n                --padding-left: var(--webien-padding-left-none);\n                }\n            <\/style><div class=\"webien-container-padding-none elementor-element elementor-element-55676ad e-con-full e-flex e-con e-child\" data-id=\"55676ad\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-31e0e6c elementor-widget elementor-widget-heading\" data-id=\"31e0e6c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">V\u00e5rt fokus<\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7a038c3 elementor-widget elementor-widget-heading\" data-id=\"7a038c3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Multipelt myelom<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a1b4517 elementor-widget elementor-widget-text-editor\" data-id=\"a1b4517\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Multipelt myelom \u00e4r en obotlig blodcancer. Symtom som skelettsm\u00e4rta, tr\u00f6tthet och infektioner minskar livskvaliteten avsev\u00e4rt. Trots framsteg inom behandlingen f\u00e5r de flesta patienter s\u00e5 sm\u00e5ningom \u00e5terfall och blir resistenta mot alla tillg\u00e4ngliga terapier, vilket skapar ett kritiskt behov av innovativa alternativ.  <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-74ddca5 elementor-widget elementor-widget-button\" data-id=\"74ddca5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/oncopeptides.com\/sv\/forskning\/multipelt-myelom\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">L\u00e4s mer<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<style>\n                .elementor-element-7343ae9{\n                --padding-top: var(--webien-padding-top-none);\n                --padding-right: var(--webien-padding-right-none);\n                --padding-bottom: var(--webien-padding-bottom-none);\n                --padding-left: var(--webien-padding-left-none);\n                }\n            <\/style><div class=\"webien-container-padding-none elementor-element elementor-element-7343ae9 e-con-full e-flex e-con e-parent\" data-id=\"7343ae9\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-fcb95b8 elementor-widget elementor-widget-spacer\" data-id=\"fcb95b8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"featured_media":0,"parent":0,"template":"","meta":{"_acf_changed":false},"protected-content":[],"class_list":["post-7429","science","type-science","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/oncopeptides.com\/sv\/wp-json\/wp\/v2\/science\/7429","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/oncopeptides.com\/sv\/wp-json\/wp\/v2\/science"}],"about":[{"href":"https:\/\/oncopeptides.com\/sv\/wp-json\/wp\/v2\/types\/science"}],"version-history":[{"count":1,"href":"https:\/\/oncopeptides.com\/sv\/wp-json\/wp\/v2\/science\/7429\/revisions"}],"predecessor-version":[{"id":7430,"href":"https:\/\/oncopeptides.com\/sv\/wp-json\/wp\/v2\/science\/7429\/revisions\/7430"}],"wp:attachment":[{"href":"https:\/\/oncopeptides.com\/sv\/wp-json\/wp\/v2\/media?parent=7429"}],"wp:term":[{"taxonomy":"protected-content","embeddable":true,"href":"https:\/\/oncopeptides.com\/sv\/wp-json\/wp\/v2\/protected-content?post=7429"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}