PDC – A true innovation
The PDC compounds are composed to enable efficient distribution in the body, enabling a wide therapeutic window (i.e. a wide margin between effective doses and doses that give unacceptable side effects), and an optimized benefit risk profile. The PDCs are designed around two components: a peptide carrier and a cytotoxic payload. The PDCs are lipophilic which allows a rapid diffusion into cells. The peptide carrier utilizes the altered metabolism of cancer cells to hydrolyze PDC into active hydrophilic metabolites, which lead to an enrichment in cancer cells.
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The SPiKE Technology Platform
This research utilizes the immune system to fight cancer. It has evolved from targeting the T-cells, such as CAR-T therapy or bi-specific antibodies, to targeting the natural killer cells, or NK-cells. This may reduce the often dose-limiting side-effects, such as cytokine release syndrome (CRS) and PNS/CNS symptoms, whilst achieving similar levels of clinical efficacy, even after previous exposure to and relapse after T-cell directed therapies. Oncopeptides has developed a proprietary technology platform for Small Polypeptide based innate Killer Engagers (SPiKE).
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